Isopropanol → HCID 9819087, compound

HRID 1532282Notes

Reaction equation

HRID 1532282 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:14])[C:9]=1[S:10]([CH3:13])(=[O:12])=[O:11])[CH:5]=O.CC(O)C.[CH3:19][C:20](=[O:25])[CH2:21][C:22](=[O:24])[CH3:23].N1CCCCC1>C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:21]([C:20](=[O:25])[CH3:19])[C:22](=[O:24])[CH3:23])[CH:7]=[C:8]([Cl:14])[C:9]=1[S:10]([CH3:13])(=[O:12])=[O:11]

Participants

6

Reactant 4

HCID 3776IsopropanolHCID 8082PiperidineHCID 31261AcetylacetoneHCID 212517313,5-Dichloro-4-(methylsulfonyl)benzaldehyde

Product 1

HCID 9819087HCID 9819087, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
23.5 °C

Procedure

3,5-Dichloro-4-(methylsulfonyl)benzaldehyde (1.5 g), 2-propanol (20 mL), 2,4-pentanedione (1.6 mL), formic acid (44 mL) and piperidine (114 mL) were mixed and stirred at 22-25° C. for 63 h. The product was filtered, washed with 2-propanol and dried (yield 1.0 g, melting point 134-136° C.). 1H-NMR(400 MHz, DMSO-d6 d=2.29 (s, 3H), 2.46 (s, 3H), 3.48 (s, 3H), 7.67 (s, 2 H), 7.71 (s, 1H).

Workup

  1. filtrationThe product was filtered
  2. washwashed with 2-propanol
  3. customdried (yield 1.0 g, melting point 134-136° C.)

Sources & evidence

ORD record
ord-512479d9b9544530a382e29ec54ba2ad
Source dataset
uspto-grants-2001_03
Patent number
US06201027B1

Reaction notes

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