反应详情

Methyl 5-(2,5-Dichlorophenyl)pentanoate (1.10 g, 4.2 mmol) was dissolved in 20 ml THF and 7 mL methanol. 1 N LiOH (12 mL) was added dropwise and the reaction was stirred at room temperature for 2 days. The reaction was worked-up by acidification with 2 N HCl and removal of most of the THF and methanol on a rotary evaporator followed by extraction of the aqueous residue with ethyl acetate. The organic phase was washed with water and saturated brine, dried over sodium sulfate and concentrated to a residue. Flash chromatography (silica gel; hexane/toluene (19/1) with 1% acetic acid) of the residue gave 725 mg (70%) of a white solid.

1. customThe reaction was worked-up by acidification with 2 N HCl and removal of most of the THF and methanol
2. customon a rotary evaporator
3. extractionfollowed by extraction of the aqueous residue with ethyl acetate
4. washThe organic phase was washed with water and saturated brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated to a residue