反应详情

To a solution of 1.31 gm (5.93 mMol) (4(S)-phenyloxazolidin-2-on-3-yl)acetic acid (Evans, U.S. Pat. No. 4,665,171) in 200 mL dichloromethane was added 0.67 mL (7.71 mMol) oxalyl chloride. To this solution was then added 0.5 mL anhydrous dimethylformamide which resulted in vigorous gas evolution. After 45 minutes all gas evolution had ceased and the reaction mixture was concentrated under reduced pressure. The title compound, recovered as an off-white solid, was dried at 0.5 mm Hg for 10 minutes before use in subsequent reactions.

1. customresulted in vigorous gas evolution
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. customThe title compound, recovered as an off-white solid
4. customwas dried at 0.5 mm Hg for 10 minutes before use in subsequent reactions