Acetate → HCID 9936216, compound

HRID 1532656Notes

Reaction equation

HRID 1532656 reaction equation
C([O-])(=O)C.[Cl:5][C:6]1[CH:37]=[CH:36][C:9]2[N:10]([CH2:30][CH2:31][CH2:32][N:33]([CH3:35])[CH3:34])[C:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[N:12][C:8]=2[CH:7]=1>C(OCC)(=O)C>[ClH:5].[Cl:5][C:6]1[CH:37]=[CH:36][C:9]2[N:10]([CH2:30][CH2:31][CH2:32][N:33]([CH3:35])[CH3:34])[C:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[N:12][C:8]=2[CH:7]=1

Participants

4

Reactant 2

HCID 175AcetateHCID 9826249HCID 9826249, compound

Product 1

HCID 9936216HCID 9936216, compoundYield 169.6%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acidlethyl acetate solution (0.24 ml) was added to a solution containing 3-(5-Chloro-2-heptadecyl-1H-benzimidazol-1-yl)-N,N-dimethyl-1-propanamine (0.46 g) in ethyl acetate (5 ml). After being stirred for 10 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethanol-ethyl acetate, thereby yielding the entitled compound (0.42 g) as white solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with the mixed solution of ethanol-ethyl acetate

Sources & evidence

ORD record
ord-31b413ae16334793804699d612d45b42
Source dataset
uspto-grants-2001_03
Patent number
US06204264B1

Reaction notes

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