HCID 9827780, compound → HCID 9827779, compound

HRID 1532678Notes

Reaction equation

HRID 1532678 reaction equation
Cl.C(OCC)(=O)C.[Cl:8][C:9]1[C:14]2[N:15]([CH2:35][CH2:36][CH2:37][N:38]([CH3:40])[CH3:39])[C:16]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[N:17][C:13]=2[CH:12]=[CH:11][CH:10]=1>C(OCC)(=O)C>[ClH:8].[Cl:8][C:9]1[C:14]2[N:15]([CH2:35][CH2:36][CH2:37][N:38]([CH3:40])[CH3:39])[C:16]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[N:17][C:13]=2[CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 9827780HCID 9827780, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 9827779HCID 9827779, compoundYield 145.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (0.19 ml) was added to a solution containing 3-(7-chloro-2-heptadecyl-1H-benzimidazol-1-yl)-N,N-dimethyl-1-propanamine (0.363 g) in ethyl acetate (3 ml). After being stirred for 10 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized with a mixed solution of ethanol-ethyl acetate, thereby yielding the entitled compound (0.284 g) as white solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with a mixed solution of ethanol-ethyl acetate

Sources & evidence

ORD record
ord-e038be2c7ba94e23a13348f83931314a
Source dataset
uspto-grants-2001_03
Patent number
US06204264B1

Reaction notes

Loading…