Potassium Carbonate → Furo[2,3-c]pyridin-5-ylmethanol

HRID 15329Notes

Reaction equation

HRID 15329 reaction equation
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]2[CH:14]=[C:13]([Si](C)(C)C)[O:12][C:9]2=[CH:10][N:11]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[O:12]1[C:9]2=[CH:10][N:11]=[C:6]([CH2:5][OH:4])[CH:7]=[C:8]2[CH:14]=[CH:13]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 57423120HCID 57423120, compound

Product 1

HCID 22047174Furo[2,3-c]pyridin-5-ylmethanolYield 90.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

[2-(Trimethylsilyl)furo[2,3-c]pyridin-5-yl]methyl acetate (1.3 g, 4.9 mmol) was dissolved in ethanol (50 ml) and treated with potassium carbonate (0.82 g, 5.9 mmol) and heated under reflux for 18 hrs. The mixture was evaporated to dryness and the residue partitioned between ethyl acetate and water. The organic layer was dried, filtered and evaporated to yield the title compound (0.66 g).

Workup

  1. temperatureheated
  2. temperatureunder reflux for 18 hrs
  3. customThe mixture was evaporated to dryness
  4. customthe residue partitioned between ethyl acetate and water
  5. customThe organic layer was dried
  6. filtrationfiltered
  7. customevaporated

Sources & evidence

ORD record
ord-e4c3c14929d3481dbdf5fef4818b6d0b
Source dataset
uspto-grants-2010_06
Patent number
US07732461B2

Reaction notes

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