Hydrochloric Acid → Viloxazine hydrochloride

HRID 1532984Notes

Reaction equation

HRID 1532984 reaction equation
C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[O:22][CH2:23][CH3:24])[CH2:9]1)C1C=CC=CC=1.[ClH:25]>C(O)C.[Pd]>[ClH:25].[CH2:23]([O:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[O:15][CH2:14][CH:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1)[CH3:24]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 1229777247374-79-8

Product 1

HCID 71424Viloxazine hydrochlorideYield 96%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The title compound was prepared by hydrogenation of (±)-4-benzyl-2-[(2-ethoxyphenoxy)-methyl]morpholine over 5% Pd/C in ethanol: 1 M aqueous HCl 3:1. mp 176-179° C. Yield 96%.

Sources & evidence

ORD record
ord-61fa7fb9104b4d309a32f21e50739f69
Source dataset
uspto-grants-2001_03
Patent number
US06207662B1

Reaction notes

Loading…