Acetic Acid → HCID 12044885, compound

HRID 1533077Notes

Reaction equation

HRID 1533077 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:16]=[C:17]([O:21][CH3:22])[C:18]=1[O:19][CH3:20])[O:6][CH2:7][C:8]([N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:9].C(O)(=O)C.[C:27]([C:29]1[CH:36]=[CH:35][C:32]([CH:33]=O)=[CH:31][CH:30]=1)#[N:28].C([BH3-])#N.[Na+]>CO>[CH3:22][O:21][C:17]1[CH:16]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:18]=1[O:19][CH3:20])[O:6][CH2:7][C:8]([N:10]1[CH2:11][CH2:12][N:13]([CH2:33][C:32]2[CH:35]=[CH:36][C:29]([C:27]#[N:28])=[CH:30][CH:31]=2)[CH2:14][CH2:15]1)=[O:9]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 660424-CyanobenzaldehydeHCID 5003444Sodium cyanoborohydrideHCID 12044886HCID 12044886, compound

Product 1

HCID 12044885HCID 12044885, compoundYield 70.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1-((3,4,5-trimethoxyphenoxy)methyl)carbonylpiperazine (0.22 g, 0.70 mmol) in a 1% acetic acid in methanol (6 mL) was added 4-cyanobenzaldehyde (0.33 g, 2.5 mmol) and sodium cyanoborohydride (0.093 g, 1.4 mmol). The resultant mixture was stirred at ambient temperature for 1.5 hours and the mixture was then concentrated of volatiles in vacuo. Residue was taken up in ethyl acetate and washed with saturated aqueous NaHCO3 solution, water, and then brine. The organic layer was separated, dried over MgSO4, filtered and concentrated in vacuo to afford a yellow oil. Purification by flash column chromatography on silica gel afforded 0.21 g of 1-((3,4,5-trimethoxyphenoxy)methyl)carbonyl-4-(4-cyanobenzyl)piperazine, a compound of formula (Ib), as a clear oil: NMR (CDCl3) 7.6 (d, 2), 7.4 (d, 2), 6.2 (s, 2), 4.6 (s, 2), 3.8 (s, 6), 3.75 (s, 3), 3.6 (m, 4), 3.5 (s, 2), 2.2 (m. 4) ppm.

Workup

  1. concentrationthe mixture was then concentrated of volatiles in vacuo
  2. washwashed with saturated aqueous NaHCO3 solution, water
  3. customThe organic layer was separated
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customto afford a yellow oil
  8. customPurification by flash column chromatography on silica gel

Sources & evidence

ORD record
ord-1ec0a5a65204460196f43fe4ebea13b4
Source dataset
uspto-grants-2001_03
Patent number
US06207665B1

Reaction notes

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