反应详情

温度

80 °C

A mixture of 2-chloro-4-nitro-1H-benzimidazole (300 mg) and N,N-dimethylethylenediamine (2 ml) were stirred at 80° C. for 8 hours. The reaction mixture was poured into saturated sodium bicarbonate aqueous solution and extracted with a mixture of chloroform and methanol. The organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was washed with diisopropyl ether to give 2-[[2-(dimethylamino)ethyl]amino]-4-nitro-1H-benzimidazole (113 mg).

1. extractionextracted with a mixture of chloroform and methanol
2. washThe organic layer was washed with brine
3. dry with materialdried over magnesium sulfate
4. customevaporated in vacuo
5. washThe residue was washed with diisopropyl ether