反应详情

To a solution of 2-amino-4-fluorophenol (40.5 g, 0.32 mole) in 400 ml tetrahydrofuran, at 0° C., was added dropwise trichloromethyl chloroformate (44.8 ml, 0.32 mole). The reaction mixture was allowed to warm up to room temperature Stirring was continued for 2 hours. Then, the reaction mixture was poured onto ice and the organic substance was extracted with ethyl acetate (500 ml×3). The combined extracts were washed with saturated sodium bicarbonate solution, dried over magnesium sulfate and concentrated to yield 44.3 g of the title compound as brown solids.

1. additionThen, the reaction mixture was poured onto ice
2. extractionthe organic substance was extracted with ethyl acetate (500 ml×3)
3. washThe combined extracts were washed with saturated sodium bicarbonate solution
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated