Benzoic Acid → Methanone, (2-(3-((1,1-dimethylethyl)amino)propoxy)phenyl)-1H-indol-4-yl-, monobenzoate

HRID 1533982Notes

Reaction equation

HRID 1533982 reaction equation
[CH3:1][C:2]([NH:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([C:18]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:19]=1[CH:20]=[CH:21][NH:22]2)=[O:17])([CH3:4])[CH3:3].[C:27]([OH:35])(=[O:34])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[C:27]([OH:35])(=[O:34])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.[CH3:4][C:2]([NH:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([C:18]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:19]=1[CH:20]=[CH:21][NH:22]2)=[O:17])([CH3:1])[CH3:3]

Participants

3

Reactant 2

HCID 243Benzoic AcidHCID 3077190HCID 3077190, compound

Product 1

HCID 3077189Methanone, (2-(3-((1,1-dimethylethyl)amino)propoxy)phenyl)-1H-indol-4-yl-, monobenzoateYield 84.5%

Procedure

Using the procedure of Step G of Example 1, 3.0 g of the product of Step F, 1.05 g of benzoic acid were reacted to obtain 3.42 g of the product melting at 162° C., which was crystallized from isopropanol to obtain 2.73 g of the desired pure product melting at 162° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-8c41d348e2634db4b408a4a48a463a59
Source dataset
uspto-grants-1992_02
Patent number
US05086070

Reaction notes

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