Benzoic Acid → HCID 19800131, compound

HRID 1533987Notes

Reaction equation

HRID 1533987 reaction equation
[C:1]([OH:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:10][C:11]([NH:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH:25]([C:27]1[C:28]2[CH:29]=[CH:30][NH:31][C:32]=2[CH:33]=[CH:34][CH:35]=1)O)([CH3:13])[CH3:12]>C(OCC)(=O)C>[C:1]([O:9][CH:25]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[O:18][CH2:17][CH2:16][CH2:15][NH:14][C:11]([CH3:13])([CH3:12])[CH3:10])[C:27]1[C:28]2[CH:29]=[CH:30][NH:31][C:32]=2[CH:33]=[CH:34][CH:35]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 243Benzoic AcidHCID 3077194HCID 3077194, compound

Product 1

HCID 19800131HCID 19800131, compoundYield 94.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of 0.745 g of benzoic acid in 11 ml of ethyl acetate was added 70° C. to a mixture of 2.15 g of product of Step A and 400 ml of ethyl acetate. The solution obtained was filtered hot and cooled to obtain 2.62 g of the desired product melting at 185° C.

Workup

  1. customThe solution obtained
  2. filtrationwas filtered hot
  3. temperaturecooled

Sources & evidence

ORD record
ord-119342c4302a4e139656dfacdc937501
Source dataset
uspto-grants-1992_02
Patent number
US05086070

Reaction notes

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