Sodium Chloride → HCID 15667144, compound

HRID 1534013Notes

Reaction equation

HRID 1534013 reaction equation
[Na].[CH3:2][C@@H:3]1[C@@H:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:6]2[C:7](Cl)=[N:8][C:9]3[N:13]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:12]=[CH:11][C:10]=3[C:5]2=[N:4]1.[O-:28][CH2:29][CH2:30][CH3:31].[Na+].[Cl-]>C(O)CC>[CH3:2][C@@H:3]1[C@@H:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:6]2[C:7]([O:28][CH2:29][CH2:30][CH3:31])=[N:8][C:9]3[N:13]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:12]=[CH:11][C:10]=3[C:5]2=[N:4]1

Participants

6

Reactant 4

HCID 5234Sodium ChlorideHCID 5360545SodiumHCID 125435151-Propanol, ion(1-)HCID 15667140(2R-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5-chloro-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine

Product 1

HCID 15667144HCID 15667144, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent2×

Procedure

51 mg sodium was dissolved in 5 ml n-propanol. 670 mg of the above product (2R-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5-chloro-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine dissolved in 15 ml n-propanol was added to the propoxide solution with stirring. After 1 hour the reaction was poured into 200 ml saturated NaCl and the extracts were dried over MgSO4, filtered and concentrated to yield an oil which was purified by radial chromatography (30-50-70-90% ethanol/hexane, 2 mm plate) to yield 600 mg of (2R-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5-propoxy-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine.

Workup

  1. dry with materialthe extracts were dried over MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customto yield an oil which
  5. customwas purified by radial chromatography (30-50-70-90% ethanol/hexane, 2 mm plate)

Sources & evidence

ORD record
ord-77b0b475b18148599138870856186091
Source dataset
uspto-grants-1992_02
Patent number
US05086176

Reaction notes

Loading…