反应详情

5 g (24 mmol) of 3-acetamido-6-acetyl-2-chloropyridine are boiled under reflux in a mixture of 25 ml of concentrated aqueous HCl and 25 ml of methanol for one hour. After cooling, the mixture is carefully added to 600 ml of saturated NaHCO3 solution and extracted three times with 200 ml of methylene chloride each time. The collected organic phases are dried with Na2SO4 and evaporated. The residue is recrystallized from toluene/petroleum ether.

1. temperatureAfter cooling
2. extractionextracted three times with 200 ml of methylene chloride each time
3. dry with materialThe collected organic phases are dried with Na2SO4
4. customevaporated
5. customThe residue is recrystallized from toluene/petroleum ether