hydroxylamine-O-sulfonic acid → 4-Ethoxy-2,3-difluorobenzonitrile

HRID 1534267Notes

Reaction equation

HRID 1534267 reaction equation
[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[C:6]([F:12])[C:5]=1[F:13])[CH3:2].[NH2:14]OS(O)(=O)=O>>[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:14])=[C:6]([F:12])[C:5]=1[F:13])[CH3:2]

Participants

3

Reactant 2

HCID 76284hydroxylamine-O-sulfonic acidHCID 144956254-Ethoxy-2,3-difluorobenzaldehyde

Product 1

HCID 144956264-Ethoxy-2,3-difluorobenzonitrile

Procedure

4-Ethoxy-2,3-difluorobenzaldehyde (obtainable according to Example 7) is reacted with hydroxylamine -O-sulfonic acid according to J. Streith and C. Fizet, Helv. Chim. Acta 59, 2796 (1976), m.p.: 45° C.

Sources & evidence

ORD record
ord-f6aa0e6a36434f9b8a74e7822875e05e
Source dataset
uspto-grants-1992_02
Patent number
US05087764

Reaction notes

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