反应详情

温度

0 °C

A solution of 0.13 mol of propionaldehyde in 30 ml of THF is added dropwise to the solution of 1,2-difluorophenyllithium in THF prepared according to 1b). The mixture is subsequently warmed to 0° C. and worked up as customary. The resulting crude product of the carbinol is dissolved in 80 ml of toluene and heated to boiling for 1 hour in a water separator with 1 g of p-TsOH. 0.2 ml of concentrated sulfuric acid are then added and the mixture is again heated for 1 hour, as above. It is then worked up as customary, b.p.30 : 105° C.

1. customprepared
2. temperatureheated
3. temperaturethe mixture is again heated for 1 hour
4. custom105° C.