反应详情

To 40 g of 10% strength palladium-carbon under nitrogen a solution of 274 g (1.26 mol) of 2-chloro-3,3,4,4-tetrafluorocyclobutenyl isopropyl ether, 252 g (2.50 mol) of triethylamine, and 1200 ml of ether dried over calcium chloride is added, and the mixture is hydrogenated in a 3 l VA autoclave at 100° C. until the pressure is constant (about 5 hours). The solid is filtered off with suction and washed well with ether, and the filtrate is washed with dilute hydrochloric acid. After drying, the organic phase is distilled.

1. additionis added
2. customis hydrogenated in a 3 l VA autoclave at 100° C. until the pressure
3. custom(about 5 hours)
4. filtrationThe solid is filtered off with suction
5. washwashed well with ether
6. washthe filtrate is washed with dilute hydrochloric acid
7. customAfter drying
8. distillationthe organic phase is distilled