(5-Methyl-2-piperidinyl)-1-pyrrolidinylmethanone → HCID 15165786, compound

HRID 1534436Notes

Reaction equation

HRID 1534436 reaction equation
[CH3:1][CH:2]1[CH2:7][NH:6][CH:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=O)[CH2:4][CH2:3]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH3:1][CH:2]1[CH2:7][NH:6][CH:5]([CH2:8][N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 19909692(5-Methyl-2-piperidinyl)-1-pyrrolidinylmethanoneHCID 21226445Aluminium lithium hydride

Product 1

HCID 15165786HCID 15165786, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By reducing g 4.5 (0.023 moles) of 5-methyl-2-(pyrrolidin-1-yl)carbonyl piperidine with LiAlH4 in THF the corresponsing diamine was obtained. The diastereoisomeric composition was checked by GLC performed on a 10 m Ph-Me silicone 50% capillary column, from 80° to 180° (rate 5° /min). Diast. A Rt 8.86 (57.93%), Diast. B. Rt 9.11 (42.07%).

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-70701c24e67844c3950818c767fe4d90
Source dataset
uspto-grants-1992_02
Patent number
US05089507

Reaction notes

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