Pyrrolidine → 2-Methyl-6-[(pyrrolidin-1-yl)methyl]pyridine

HRID 1534437Notes

Reaction equation

[CH3:1][C:2]1[N:7]=[C:6]([CH2:8]O)[CH:5]=[CH:4][CH:3]=1.CS(Cl)(=O)=O.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH3:1][C:2]1[N:7]=[C:6]([CH2:8][N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH:5]=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 31268Pyrrolidine

HCID 31297Methanesulfonyl chloride

HCID 707366-Methyl-2-pyridylmethanol

Product 1

HCID 151232652-Methyl-6-[(pyrrolidin-1-yl)methyl]pyridine

Procedure

By reaction of 6-methyl-2-pyridyl methanol [prepared as described in Helv. Chim. Acta, 2429 (1957)], g 7.1 (0.058 moles), with methanesulfonyl chloride and then with pyrrolidine as in Description 1, g 7.5 of yellow oil (b.p. 62°-65° C. 80 mmHg) were obtained.

Workup

customwere obtained

Sources & evidence

ORD record: ord-fbbafb301d894a4f834c540c6e0fd507
Source dataset: uspto-grants-1992_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05089507

Reaction notes

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