Hydrochloric Acid → (5-Methyl-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-3-yl)methanone

HRID 1534635Notes

Reaction equation

HRID 1534635 reaction equation
Cl.[C:2](Cl)(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1.[CH3:11][CH:12]1[NH:16][N:15]=[CH:14][CH2:13]1.C(N(CC)CC)C>C(Cl)(Cl)Cl>[N:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([N:16]2[CH:12]([CH3:11])[CH2:13][CH:14]=[N:15]2)=[O:9])[CH:4]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 82604Nicotinoyl chlorideHCID 5497805-methyl-4,5-dihydro-1H-pyrazole

Product 1

HCID 3078468(5-Methyl-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-3-yl)methanone

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Hydrochloride of nicotinic acid chloride (4 g) was suspended in 20 ml of chloroform followed by addition of a mixture of 1.7 g of 5-methyl-2-pyrazoline and 4 g of triethylamine, washing with water and concentration. The product was purified by chromatography on a silica gel column (chloroform/methanol=100/1). Yield; 3.4 g.

Workup

  1. washwashing with water and concentration
  2. customThe product was purified by chromatography on a silica gel column (chloroform/methanol=100/1)

Sources & evidence

ORD record
ord-8614747a1d9c4f02adef2accbbe11035
Source dataset
uspto-grants-1992_02
Patent number
US05089622

Reaction notes

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