Hydrochloric Acid → Azetidin-3-yl(3,5-difluorophenyl)methanone

HRID 1535181Notes

Reaction equation

HRID 1535181 reaction equation
[ClH:29].[F:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[CH:7]2[CH2:8][N:9]([C:11]([O:12][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:17])[CH2:10]2)[cH:18][c:19]([F:21])[cH:20]1.[F:22][C:23]([F:24])([F:25])[C:26]([OH:27])=[O:28].[O:30]1[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1>>[F:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[CH:7]2[CH2:8][NH:9][CH2:10]2)[cH:18][c:19]([F:21])[cH:20]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 312751,4-DioxaneHCID 670659051,1-Dimethylethyl 3-(3,5-difluorobenzoyl)-1-azetidinecarboxylate

Product 1

HCID 67065914Azetidin-3-yl(3,5-difluorophenyl)methanone

Sources & evidence

ORD record
ord-ddeb074469224c609b9fcf6fef0b2620
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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