Dichloromethane → N-[5-chloro-7-(3-methoxyprop-1-yn-1-yl)-1,3-benzodioxol-4-yl]-7-{3-[4-(2-fluoroethyl)piperazin-1-yl]propoxy}-6-methoxyquinazolin-4-amine
Reaction equation
[CH3:52][O:53][CH2:54][CH2:55][OH:56].[CH:43]([N:44]([CH:45]([CH3:46])[CH3:47])[CH2:48][CH3:49])([CH3:50])[CH3:51].[Cl:1][c:2]1[c:3]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][c:23]([O:29][CH2:30][CH2:31][CH2:32][Cl:33])[c:24]([O:27][CH3:28])[cH:25][c:26]23)[c:4]2[c:5]([c:9]([C:11]#[C:12][CH2:13][O:14][CH3:15])[cH:10]1)[O:6][CH2:7][O:8]2.[Cl:57][CH2:58][Cl:59].[F:34][CH2:35][CH2:36][N:37]1[CH2:38][CH2:39][NH:40][CH2:41][CH2:42]1>>[Cl:1][c:2]1[c:3]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][c:23]([O:29][CH2:30][CH2:31][CH2:32][N:40]4[CH2:39][CH2:38][N:37]([CH2:36][CH2:35][F:34])[CH2:42][CH2:41]4)[c:24]([O:27][CH3:28])[cH:25][c:26]23)[c:4]2[c:5]([c:9]([C:11]#[C:12][CH2:13][O:14][CH3:15])[cH:10]1)[O:6][CH2:7][O:8]2Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-85de8b7a420b4a2ea7e9959f3932295f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
Loading…