Tetrahydrofuran → Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

HRID 153666Notes

Reaction equation

HRID 153666 reaction equation
[Al+3:20].[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[H-:19].[H-:22].[H-:23].[H-:24].[Li+:21].[N:1]1([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:2][CH2:3][CH:4]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[CH2:5][CH2:6]1>>[N:1]1([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:2][CH2:3][CH:4]([CH2:7][OH:8])[CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 27588121-Tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

Product 1

HCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-743d5aa3384c4a2e9ff3622177255c0c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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