Sodium ion → 2-{2-Chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}-4-(methoxycarbonyl)methoxypyrimidine

HRID 1536832Notes

Reaction equation

HRID 1536832 reaction equation
[Br:32][CH2:33][C:34](=[O:35])[O:36][CH3:37].[CH3:38][N:39]([CH3:40])[CH:41]=[O:42].[Cl:3][c:4]1[c:5]([O:6][c:7]2[n:8][cH:9][cH:10][c:11]([OH:13])[n:12]2)[cH:14][c:15](-[n:19]2[c:20](=[O:31])[n:21]([CH3:30])[c:22]([C:26]([F:27])([F:28])[F:29])[cH:23][c:24]2=[O:25])[c:16]([F:18])[cH:17]1.[H-:1].[Na+:2].[OH2:43]>>[Cl:3][c:4]1[c:5]([O:6][c:7]2[n:8][cH:9][cH:10][c:11]([O:13][CH2:33][C:34](=[O:35])[O:36][CH3:37])[n:12]2)[cH:14][c:15](-[n:19]2[c:20](=[O:31])[n:21]([CH3:30])[c:22]([C:26]([F:27])([F:28])[F:29])[cH:23][c:24]2=[O:25])[c:16]([F:18])[cH:17]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 60984Methyl bromoacetateHCID 166653HydrideHCID 178480550HCID 178480550, compound

Product 1

HCID 186191982-{2-Chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]phenoxy}-4-(methoxycarbonyl)methoxypyrimidine

Sources & evidence

ORD record
ord-605ffdf99a0047e8836821c7f21ff3a8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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