2-Iodotoluene → 1-(3-o-Tolyl-2-propynyl)piperidine

HRID 1536873Notes

Reaction equation

HRID 1536873 reaction equation
[CH2:18]([NH:19][CH2:20][CH3:21])[CH3:22].[CH2:9]([C:10]#[CH:11])[N:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1.[Cl:23][Pd-2:24]([Cl:25])([PH:26]([c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)([c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1)[c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1)[PH:45]([c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1)([c:52]1[cH:53][cH:54][cH:55][cH:56][cH:57]1)[c:58]1[cH:59][cH:60][cH:61][cH:62][cH:63]1.[Cu:64][I:65].[I:1][c:2]1[c:3]([CH3:8])[cH:4][cH:5][cH:6][cH:7]1>>[c:2]1([C:11]#[C:10][CH2:9][N:12]2[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)[c:3]([CH3:8])[cH:4][cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 51282-IodotolueneHCID 8021DiethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 3366521-(Prop-2-yn-1-yl)piperidineHCID 178418903HCID 178418903, compound

Product 1

HCID 120567831-(3-o-Tolyl-2-propynyl)piperidine

Sources & evidence

ORD record
ord-d0868294dd2647a19de180aaad27c97d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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