Tetrahydrofuran → 6-Chloro-2-(4-(1,4-dimethylpiperidin-4-yl)phenylamino)-5-fluoronicotinamide
Reaction equation
[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH3:13][N:14]1[CH2:15][CH2:16][C:17]([CH3:20])([c:21]2[cH:22][cH:23][c:24]([NH2:25])[cH:26][cH:27]2)[CH2:18][CH2:19]1.[CH3:28][Si:29]([N-:30][Si:31]([CH3:32])([CH3:33])[CH3:34])([CH3:35])[CH3:36].[Cl:1][c:2]1[c:3]([C:4](=[O:5])[NH2:6])[cH:7][c:8]([F:12])[c:9]([Cl:11])[n:10]1.[Li+:37]>>[c:2]1([NH:25][c:24]2[cH:23][cH:22][c:21]([C:17]3([CH3:20])[CH2:16][CH2:15][N:14]([CH3:13])[CH2:19][CH2:18]3)[cH:27][cH:26]2)[c:3]([C:4](=[O:5])[NH2:6])[cH:7][c:8]([F:12])[c:9]([Cl:11])[n:10]1Participants
6
Sources & evidence
- ORD record
- ord-aaaee3def8944575af64f0ec220dfb4a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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