Dimethylformamide → Ethyl 2-[2-(2,4-difluorophenylamino)-6-ethylthio-5-fluoronicotinoyl]acetate

HRID 1538446Notes

Reaction equation

HRID 1538446 reaction equation
[CH2:38]([CH3:39])[SH:40].[CH3:41][CH2:42][N:43]([CH2:44][CH3:45])[CH2:46][CH3:47].[CH3:48][N:49]([CH3:50])[CH:51]=[O:52].[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:12](=[O:13])[CH2:14][C:15](=[O:16])[O:17][CH2:18][CH3:19])[cH:20][c:21]([F:37])[c:22]([O:24][S:25]([c:26]3[c:27]([CH3:28])[cH:29][c:30]([CH3:31])[cH:32][c:33]3[CH3:34])(=[O:35])=[O:36])[n:23]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1>>[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:12](=[O:13])[CH2:14][C:15](=[O:16])[O:17][CH2:18][CH3:19])[cH:20][c:21]([F:37])[c:22]([S:40][CH2:38][CH3:39])[n:23]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6343EthanethiolHCID 8471TriethylamineHCID 13849317Ethyl 2-[2-(2,4-difluorophenylamino)-5-fluoro-6-(2,4,6-trimethylbenzenesulfonyloxy)nicotinoyl]acetate

Product 1

HCID 13849319Ethyl 2-[2-(2,4-difluorophenylamino)-6-ethylthio-5-fluoronicotinoyl]acetate

Sources & evidence

ORD record
ord-84b825b3b8514c6d9ab3fd90cd249a7b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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