Methanesulfonic Acid → HCID 131728175, compound

HRID 15390Notes

Reaction equation

HRID 15390 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]([N:13]1[CH2:21][C:17]2[CH:18]=[CH:19][S:20][C:16]=2[CH2:15][CH2:14]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=1[Cl:12])=[O:4].[CH3:22][S:23]([OH:26])(=[O:25])=[O:24]>CO>[CH3:1][O:2][C:3]([C@@H:5]([N:13]1[CH2:21][C:17]2[CH:18]=[CH:19][S:20][C:16]=2[CH2:15][CH2:14]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=1[Cl:12])=[O:4].[S:23]([O-:26])(=[O:25])(=[O:24])[CH3:22]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 60606Clopidogrel

Product 1

HCID 131728175HCID 131728175, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Clopidogrel base was dissolved in methanol to obtain a clear solution. Methanesulfonic acid was added to the solution at 20° C. The reaction mixture was heated to reflux temperature for 2 to 10 hrs. The solvent was evaporated to dryness under reduced pressure to obtain the title compound.

Workup

  1. customto obtain a clear solution
  2. temperatureThe reaction mixture was heated
  3. temperatureto reflux temperature for 2 to 10 hrs
  4. customThe solvent was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-22cad0c2ae7a45ccb8f724d674d8204a
Source dataset
uspto-grants-2010_06
Patent number
US07732608B2

Reaction notes

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