Dimethylformamide → Ethyl 8,9dimethoxy-3-methyl-2-(3-pyrrolidinyl-phenyl)-5,6-dihydro-pyrrolo[2,1-a]-isoquinoline-1-carboxylate

HRID 1539864Notes

Reaction equation

HRID 1539864 reaction equation
[Br:12][CH2:13][CH2:14][CH2:15][CH2:16][Br:17].[CH2:1]1[CH2:2][CH2:3][N:6]2[C:5](=[N:10][CH2:9][CH2:8][CH2:7]2)[CH2:4][CH2:11]1.[NH2:18][c:19]1[cH:20][c:21](-[c:25]2[c:26]([C:43](=[O:44])[O:45][CH2:46][CH3:47])[c:27]3[n:28]([c:41]2[CH3:42])[CH2:29][CH2:30][c:31]2[cH:32][c:33]([O:39][CH3:40])[c:34]([O:37][CH3:38])[cH:35][c:36]2-3)[cH:22][cH:23][cH:24]1.[O:48]=[CH:49][N:50]([CH3:51])[CH3:52]>>[CH2:1]1[CH2:2][CH2:3][N:18]([c:19]2[cH:20][c:21](-[c:25]3[c:26]([C:43](=[O:44])[O:45][CH2:46][CH3:47])[c:27]4[n:28]([c:41]3[CH3:42])[CH2:29][CH2:30][c:31]3[cH:32][c:33]([O:39][CH3:40])[c:34]([O:37][CH3:38])[cH:35][c:36]3-4)[cH:22][cH:23][cH:24]2)[CH2:11]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 80561,4-DibromobutaneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 10179495Ethyl 2-(3-aminophenyl)-8,9-dimethoxy-3-methyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-1-carboxylate

Product 1

HCID 20823072Ethyl 8,9dimethoxy-3-methyl-2-(3-pyrrolidinyl-phenyl)-5,6-dihydro-pyrrolo[2,1-a]-isoquinoline-1-carboxylate

Sources & evidence

ORD record
ord-5be15f894f9742649a4c85a99ba2a86e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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