Amantadine → N-adamantan-1-yl-2,6-dichloronicotinamide
Reaction equation
[CH2:23]([N:24]([CH:25]([CH3:26])[CH3:27])[CH:28]([CH3:29])[CH3:30])[CH3:31].[CH3:35][CH2:36][O:37][C:38]([CH3:39])=[O:40].[Cl:1][c:2]1[c:3]([C:4](=[O:5])[Cl:6])[cH:7][cH:8][c:9]([Cl:11])[n:10]1.[Cl:32][CH2:33][Cl:34].[NH2:12][C:13]12[CH2:14][CH:15]3[CH2:16][CH:17]([CH2:18][CH:19]([CH2:20]1)[CH2:21]3)[CH2:22]2>>[Cl:1][c:2]1[c:3]([C:4](=[O:5])[NH:12][C:13]23[CH2:14][CH:15]4[CH2:16][CH:17]([CH2:18][CH:19]([CH2:20]2)[CH2:21]4)[CH2:22]3)[cH:7][cH:8][c:9]([Cl:11])[n:10]1Participants
6
Sources & evidence
- ORD record
- ord-66ac5c0e8f5541abb7a112f2a32802ee
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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