Hydrochloric Acid → 4-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}-N-isopropylpiperidine-1-carboxamide

HRID 1541141Notes

Reaction equation

HRID 1541141 reaction equation
[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([c:8]2[n:9][c:10]([NH2:31])[n:11][c:12]([N:14]3[CH2:15][c:16]4[cH:17][c:18]([CH:25]5[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]5)[cH:19][cH:20][c:21]4[CH2:22][CH:23]3[CH3:24])[cH:13]2)[CH2:6][CH2:7]1.[ClH:32].[N:33](=[C:34]=[O:35])[CH:36]([CH3:37])[CH3:38]>>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([c:8]2[n:9][c:10]([NH2:31])[n:11][c:12]([N:14]3[CH2:15][c:16]4[cH:17][c:18]([CH:25]5[CH2:26][CH2:27][N:28]([C:34]([NH:33][CH:36]([CH3:37])[CH3:38])=[O:35])[CH2:29][CH2:30]5)[cH:19][cH:20][c:21]4[CH2:22][CH:23]3[CH3:24])[cH:13]2)[CH2:6][CH2:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 61277Isopropyl isocyanateHCID 59402258HCID 59402258, compound

Product 1

HCID 594023804-{2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}-N-isopropylpiperidine-1-carboxamide

Sources & evidence

ORD record
ord-103fb98f5b51485db1970bfca8128070
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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