Chloroform → 3-[[2-(1-tert-Butoxycarbonylpiperid-4-yl)ethyl]-amino]-5,6-dichloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one

HRID 1541402Notes

Reaction equation

HRID 1541402 reaction equation
[Br:24][C:25]1([c:37]2[c:38]([Cl:43])[cH:39][cH:40][cH:41][cH:42]2)[C:26](=[O:36])[NH:27][c:28]2[cH:29][c:30]([Cl:35])[c:31]([Cl:34])[cH:32][c:33]21.[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[CH3:17][CH2:18][N:19]([CH2:20][CH3:21])[CH2:22][CH3:23].[CH:44]([Cl:45])([Cl:46])[Cl:47].[NH2:1][CH2:2][CH2:3][CH:4]1[CH2:5][CH2:6][N:7]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:8][CH2:9]1>>[NH:1]([CH2:2][CH2:3][CH:4]1[CH2:5][CH2:6][N:7]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:8][CH2:9]1)[C:25]1([c:37]2[c:38]([Cl:43])[cH:39][cH:40][cH:41][cH:42]2)[C:26](=[O:36])[NH:27][c:28]2[cH:29][c:30]([Cl:35])[c:31]([Cl:34])[cH:32][c:33]21

Participants

6

Reactant 5

HCID 6212ChloroformHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 1514258tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylateHCID 219059233-Bromo-5,6-dichloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one

Product 1

HCID 190764883-[[2-(1-tert-Butoxycarbonylpiperid-4-yl)ethyl]-amino]-5,6-dichloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one

Sources & evidence

ORD record
ord-2cd350b07199455b9d0dc093af961709
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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