Dimethylformamide → 4-chloro-N-(4-chloro-3-(2-(2-(dimethylamino)ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide

HRID 1541497Notes

Reaction equation

HRID 1541497 reaction equation
[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[Cl:59][c:60]1[c:61]([C:69]([F:70])([F:71])[F:72])[cH:62][c:63]([C:64](=[O:65])[OH:66])[cH:67][cH:68]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([Cl:27])[c:6](-[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]([NH:16][CH2:17][CH2:18][N:19]([CH3:20])[CH3:21])[n:14][cH:15]3)[n:22]([O:25][CH3:26])[c:23]2=[O:24])[cH:7]1.[O:73]=[CH:74][N:75]([CH3:76])[CH3:77].[P-:35]([F:36])([F:37])([F:38])([F:39])([F:40])[F:41].[n:42]1([O:43][C:44]([N:45]([CH3:46])[CH3:47])=[N+:48]([CH3:49])[CH3:50])[c:51]2[n:52][cH:53][cH:54][cH:55][c:56]2[n:57][n:58]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([Cl:27])[c:6](-[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]([NH:16][CH2:17][CH2:18][N:19]([CH3:20])[CH3:21])[n:14][cH:15]3)[n:22]([O:25][CH3:26])[c:23]2=[O:24])[cH:7]1)[C:64]([c:63]1[cH:62][c:61]([C:69]([F:70])([F:71])[F:72])[c:60]([Cl:59])[cH:68][cH:67]1)=[O:65]

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 27738574-Chloro-3-(trifluoromethyl)benzoic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 584783586-(5-amino-2-chlorophenyl)-2-(2-(dimethylamino)ethylamino)-8-methoxypyrido[2,3-d]pyrimidin-7(8H)-one

Product 1

HCID 444661624-chloro-N-(4-chloro-3-(2-(2-(dimethylamino)ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide

Sources & evidence

ORD record
ord-19821602755e430eb42f727e5cb9388d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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