Acetonitrile → 4-{7-[3-(2-Oxo-pyrrolidin-1-yl)-propoxy]-quinazolin-4-yl}-piperidine-1-carboxylic acid (4-isopropoxy-phenyl)-amide
Reaction equation
[C:1]([O:2][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[n:15][cH:16][n:17][c:18]3[cH:19][c:20]([O:24][CH2:25][CH2:26][CH2:27][N:28]4[C:29](=[O:33])[CH2:30][CH2:31][CH2:32]4)[cH:21][cH:22][c:23]23)[CH2:12][CH2:13]1)([CH3:3])([CH3:4])[CH3:5].[CH3:76][C:77]#[N:78].[CH:67]([N:68]([CH2:69][CH3:70])[CH:71]([CH3:72])[CH3:73])([CH3:74])[CH3:75].[Cl:41][CH2:42][Cl:43].[F:34][C:35]([F:36])([F:37])[C:38]([OH:39])=[O:40].[N+:44]([c:45]1[cH:46][cH:47][c:48]([O:49][C:50](=[O:51])[NH:55][c:56]2[cH:57][cH:58][c:59]([O:62][CH:63]([CH3:64])[CH3:65])[cH:60][cH:61]2)[cH:52][cH:53]1)([O-:54])=[O:66]>>[C:6](=[O:7])([N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[n:15][cH:16][n:17][c:18]3[cH:19][c:20]([O:24][CH2:25][CH2:26][CH2:27][N:28]4[C:29](=[O:33])[CH2:30][CH2:31][CH2:32]4)[cH:21][cH:22][c:23]23)[CH2:12][CH2:13]1)[NH:55][c:56]1[cH:57][cH:58][c:59]([O:62][CH:63]([CH3:64])[CH3:65])[cH:60][cH:61]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-7daa0c4fc6ee40aa947efbb14ee88451
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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