Diethyl Ether → 4-(2,4-Dichloro-5-methoxyanilino)-7-(2-formyl-3-methylimidazol-4-yl)quinoline-3-carbonitrile
Reaction equation
[Br:22][c:23]1[cH:24][cH:25][c:26]2[c:27]([NH:35][c:36]3[c:37]([Cl:45])[cH:38][c:39]([Cl:44])[c:40]([O:42][CH3:43])[cH:41]3)[c:28]([C:33]#[N:34])[cH:29][n:30][c:31]2[cH:32]1.[CH2:59]([O:60][CH2:61][CH3:62])[CH3:63].[CH3:1][n:2]1[c:3]([CH:20]=[O:21])[n:4][cH:5][c:6]1[Sn:7]([CH2:8][CH2:9][CH2:10][CH3:11])([CH2:12][CH2:13][CH2:14][CH3:15])[CH2:16][CH2:17][CH2:18][CH3:19].[CH3:46][CH2:47][N:48]([CH2:49][CH3:50])[CH2:51][CH3:52].[CH3:53][CH2:54][CH2:55][CH2:56][CH2:57][CH3:58].[O:64]1[CH2:65][CH2:66][O:67][CH2:68][CH2:69]1.[Pd:70]([Cl:71])[Cl:72].[c:73]1([P:74]([c:75]2[cH:76][cH:77][cH:78][cH:79][cH:80]2)[c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)[cH:87][cH:88][cH:89][cH:90][cH:91]1.[c:92]1([P:93]([c:94]2[cH:95][cH:96][cH:97][cH:98][cH:99]2)[c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)[cH:106][cH:107][cH:108][cH:109][cH:110]1>>[CH3:1][n:2]1[c:3]([CH:20]=[O:21])[n:4][cH:5][c:6]1-[c:23]1[cH:24][cH:25][c:26]2[c:27]([NH:35][c:36]3[c:37]([Cl:45])[cH:38][c:39]([Cl:44])[c:40]([O:42][CH3:43])[cH:41]3)[c:28]([C:33]#[N:34])[cH:29][n:30][c:31]2[cH:32]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-fb2c564b13f444918f2d6e6948945dc0
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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