Trifluoroacetic acid → 7-Chloro-6-nitro-4-(2-piperidin-2-yl-ethoxy)-3-thiophen-2-yl-1H-quinolin-2-one

HRID 1541861Notes

Reaction equation

HRID 1541861 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH:9]([CH2:14][CH2:15][O:16][c:17]2[c:18](-[c:32]3[s:33][cH:34][cH:35][cH:36]3)[c:19](=[O:31])[nH:20][c:21]3[cH:22][c:23]([Cl:30])[c:24]([N+:27](=[O:28])[O-:29])[cH:25][c:26]23)[CH2:10][CH2:11][CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH3:37][O:38][c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1.[OH:45][C:46]([C:47]([F:48])([F:49])[F:50])=[O:51]>>[NH:8]1[CH:9]([CH2:14][CH2:15][O:16][c:17]2[c:18](-[c:32]3[s:33][cH:34][cH:35][cH:36]3)[c:19](=[O:31])[nH:20][c:21]3[cH:22][c:23]([Cl:30])[c:24]([N+:27](=[O:28])[O-:29])[cH:25][c:26]23)[CH2:10][CH2:11][CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 536939232-[2-(7-Chloro-6-nitro-2-oxo-3-thiophen-2-yl-1,2-dihydro-quinolin-4-yloxy)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 98457627-Chloro-6-nitro-4-(2-piperidin-2-yl-ethoxy)-3-thiophen-2-yl-1H-quinolin-2-one

Sources & evidence

ORD record
ord-5833fe6460224ddba177062d4ef02513
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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