Trifluoroacetic acid → 3-Fluoro4-[4-pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenol

HRID 154193Notes

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]([F:31])[c:12](-[c:15]2[n:16][n:17]([CH2:26][C:27]([F:28])([F:29])[F:30])[cH:18][c:19]2-[c:20]2[cH:21][cH:22][n:23][cH:24][cH:25]2)[cH:13][cH:14]1.[CH3:39][O:40][c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1.[OH:32][C:33]([C:34]([F:35])([F:36])[F:37])=[O:38]>>[OH:8][c:9]1[cH:10][c:11]([F:31])[c:12](-[c:15]2[n:16][n:17]([CH2:26][C:27]([F:28])([F:29])[F:30])[cH:18][c:19]2-[c:20]2[cH:21][cH:22][n:23][cH:24][cH:25]2)[cH:13][cH:14]1

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 7519Anisole

HCID 685753054-[3-(4-Benzyloxy-2-fluoro-phenyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-pyridine

Product 1

HCID 1363758193-Fluoro4-[4-pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenol

Sources & evidence

ORD record: ord-20de45885d234b3f83916762cd4b4f9e
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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