Water → 4-(5-Fluoro-2-mercapto-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[Br:1][c:2]1[c:3]([SH:9])[cH:4][cH:5][c:6]([F:8])[cH:7]1.[C:12]([Li:13])([CH3:14])([CH3:15])[CH3:16].[C:17]([CH3:18])([CH3:19])([CH3:20])[O:21][C:22](=[O:23])[N:24]1[CH2:25][CH2:26][C:27](=[O:30])[CH2:28][CH2:29]1.[CH3:10][Li:11].[CH3:36][CH2:37][O:38][C:39](=[O:40])[CH3:41].[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1.[OH2:42]>>[c:2]1([C:27]2([OH:30])[CH2:26][CH2:25][N:24]([C:22]([O:21][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:23])[CH2:29][CH2:28]2)[c:3]([SH:9])[cH:4][cH:5][c:6]([F:8])[cH:7]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-d7256e5b845c416dabd4a4f6dca82f64
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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