Dimethylformamide → 6-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-tert-butoxy-ethoxy)-amide

HRID 1543825Notes

Reaction equation

HRID 1543825 reaction equation
[C:55]([CH3:56])([CH3:57])([CH3:58])[O:59][CH2:60][CH2:61][O:62][NH2:63].[CH3:48][N:49]1[CH2:50][CH2:51][O:52][CH2:53][CH2:54]1.[F:1][c:2]1[c:3](=[O:23])[n:4]2[c:8]([c:9]([C:20](=[O:21])[OH:22])[c:10]1[NH:11][c:12]1[c:13]([F:19])[cH:14][c:15]([I:18])[cH:16][cH:17]1)[CH2:7][CH2:6][CH2:5]2.[O:64]=[CH:65][N:66]([CH3:67])[CH3:68].[P-:24]([F:25])([F:26])([F:27])([F:28])([F:29])[F:30].[n:31]1([O:32][C:33]([N:34]([CH3:35])[CH3:36])=[N+:37]([CH3:38])[CH3:39])[c:40]2[n:41][cH:42][cH:43][cH:44][c:45]2[n:46][n:47]1>>[F:1][c:2]1[c:3](=[O:23])[n:4]2[c:8]([c:9]([C:20](=[O:22])[NH:63][O:62][CH2:61][CH2:60][O:59][C:55]([CH3:56])([CH3:57])[CH3:58])[c:10]1[NH:11][c:12]1[c:13]([F:19])[cH:14][c:15]([I:18])[cH:16][cH:17]1)[CH2:7][CH2:6][CH2:5]2

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 79724-MethylmorpholineHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 252657696-Fluoro-7-(2-fluoro-4-iodophenylamino)-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylic acidHCID 46856370O-(2-tert-butoxyethyl)hydroxylamine

Product 1

HCID 576898066-Fluoro-7-(2-fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid (2-tert-butoxy-ethoxy)-amide

Sources & evidence

ORD record
ord-8b4c7425b5f1471ab59fa021cb37ae95
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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