Dimethylformamide → 5-Chloro-1-{2-[4-(4-chloro-3-methoxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methyl-1,3-dihydro-benzoimidazol-2-one

HRID 1544610Notes

Reaction equation

HRID 1544610 reaction equation
[C:32](=[O:33])([O-:34])[O-:35].[CH3:43][CH2:44][O:45][C:46](=[O:47])[CH3:48].[Cl:13][CH2:14][C:15](=[O:16])[N:17]1[CH2:18][CH2:19][N:20]([c:23]2[cH:24][c:25]([O:30][CH3:31])[c:26]([Cl:29])[cH:27][cH:28]2)[CH2:21][CH2:22]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]([CH3:11])[c:8](=[O:10])[nH:9]2)[cH:12]1.[Cs+:36].[Cs+:37].[O:38]=[CH:39][N:40]([CH3:41])[CH3:42]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]([CH3:11])[c:8](=[O:10])[n:9]2[CH2:14][C:15](=[O:16])[N:17]2[CH2:18][CH2:19][N:20]([c:23]3[cH:24][c:25]([O:30][CH3:31])[c:26]([Cl:29])[cH:27][cH:28]3)[CH2:21][CH2:22]2)[cH:12]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 140429442H-Benzimidazol-2-one,6-chloro-1,3-dihydro-1-methyl-(9CI)HCID 210711262-Chloro-1-(4-(4-chloro-3-methoxyphenyl)piperazin-1-yl)ethanone

Product 1

HCID 160596335-Chloro-1-{2-[4-(4-chloro-3-methoxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3-methyl-1,3-dihydro-benzoimidazol-2-one

Sources & evidence

ORD record
ord-a024ed898778497b8bc8b43c10674ec3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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