1,2-Dichloroethane → (5-{3-[(5-bromo-pyridine-2-carbonyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester
Reaction equation
[Br:23][c:24]1[cH:25][cH:26][c:27]([C:30](=[O:31])[OH:32])[n:28][cH:29]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([CH3:14])([c:15]2[cH:16][c:17]([NH2:21])[cH:18][cH:19][cH:20]2)[CH2:11][O:10][CH2:9]1)=[O:22].[CH2:52]([Cl:53])[CH2:54][Cl:55].[CH:43]([N:44]([CH2:45][CH3:46])[CH:47]([CH3:48])[CH3:49])([CH3:50])[CH3:51].[Cl:56][CH2:57][Cl:58].[OH:33][n:34]1[c:35]2[c:36]([cH:37][cH:38][cH:39][cH:40]2)[n:41][n:42]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1=[N:13][C:12]([CH3:14])([c:15]2[cH:16][c:17]([NH:21][C:30]([c:27]3[cH:26][cH:25][c:24]([Br:23])[cH:29][n:28]3)=[O:31])[cH:18][cH:19][cH:20]2)[CH2:11][O:10][CH2:9]1)=[O:22]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-97e8b4cde7e04cf28ced0e34f188386c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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