Dichloromethane → 3-(4-methoxy-phenyl)-1-(trans-4-hydroxy-cyclohexyl)-7-(4-methoxy-phenylamino)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

HRID 1545866Notes

Reaction equation

HRID 1545866 reaction equation
[C:1]([Si:2]([CH3:3])([CH3:4])[O:6][CH:7]1[CH2:8][CH2:9][CH:10]([N:13]2[C:14](=[O:40])[N:15]([c:32]3[cH:33][cH:34][c:35]([O:38][CH3:39])[cH:36][cH:37]3)[CH2:16][c:17]3[c:18]2[n:19][c:20]([NH:23][c:24]2[cH:25][cH:26][c:27]([O:30][CH3:31])[cH:28][cH:29]2)[n:21][cH:22]3)[CH2:11][CH2:12]1)([CH3:5])([CH3:41])[CH3:42].[CH3:53][CH2:54][O:55][C:56](=[O:57])[CH3:58].[Cl:50][CH2:51][Cl:52].[OH:43][C:44]([C:45]([F:46])([F:47])[F:48])=[O:49]>>[OH:6][CH:7]1[CH2:8][CH2:9][CH:10]([N:13]2[C:14](=[O:40])[N:15]([c:32]3[cH:33][cH:34][c:35]([O:38][CH3:39])[cH:36][cH:37]3)[CH2:16][c:17]3[c:18]2[n:19][c:20]([NH:23][c:24]2[cH:25][cH:26][c:27]([O:30][CH3:31])[cH:28][cH:29]2)[n:21][cH:22]3)[CH2:11][CH2:12]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 114107401-[trans-4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-3-(4-methoxy-phenyl)-7-(4-methoxy-phenylamino)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

Product 1

HCID 112944753-(4-methoxy-phenyl)-1-(trans-4-hydroxy-cyclohexyl)-7-(4-methoxy-phenylamino)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

Sources & evidence

ORD record
ord-cce2d1ac53894c01ac58c4a0188ba8cb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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