Dimethyl Sulfoxide → [4-bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-yl]-(3-methoxy-phenyl)-methanone

HRID 1547225Notes

Reaction equation

HRID 1547225 reaction equation
[Br:7][c:8]1[c:9]([CH:32]([OH:33])[c:34]2[cH:35][c:36]([O:40][CH3:41])[cH:37][cH:38][cH:39]2)[cH:10][c:11]([O:30][CH3:31])[c:12]2[n:13]([CH2:26][CH2:27][O:28][CH3:29])[c:14](-[c:17]3[cH:18][cH:19][c:20]([CH:23]([CH3:24])[CH3:25])[cH:21][cH:22]3)[n:15][c:16]12.[C:1]([Cl:2])(=[O:3])[C:4]([Cl:5])=[O:6].[CH3:42][CH2:43][N:44]([CH2:45][CH3:46])[CH2:47][CH3:48].[CH3:52][S:53]([CH3:54])=[O:55].[Cl:49][CH2:50][Cl:51]>>[Br:7][c:8]1[c:9]([C:32](=[O:33])[c:34]2[cH:35][c:36]([O:40][CH3:41])[cH:37][cH:38][cH:39]2)[cH:10][c:11]([O:30][CH3:31])[c:12]2[n:13]([CH2:26][CH2:27][O:28][CH3:29])[c:14](-[c:17]3[cH:18][cH:19][c:20]([CH:23]([CH3:24])[CH3:25])[cH:21][cH:22]3)[n:15][c:16]12

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 57772052[4-Bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-yl]-(3-methoxy-phenyl)-methanol

Product 1

HCID 11191900[4-bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-yl]-(3-methoxy-phenyl)-methanone

Sources & evidence

ORD record
ord-218066e0a0704d41a0f011a2202e6ded
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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