Dimethylformamide → 2,6-Dichloro-N-cyclopropylisonicotinamide

HRID 1549408Notes

Reaction equation

[CH:12]1([NH2:15])[CH2:13][CH2:14]1.[CH:16]([N:17]([CH2:18][CH3:19])[CH:20]([CH3:21])[CH3:22])([CH3:23])[CH3:24].[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[OH:7])[cH:8][c:9]([Cl:11])[n:10]1.[O:49]=[CH:50][N:51]([CH3:52])[CH3:53].[P-:25]([F:26])([F:27])([F:28])([F:29])([F:30])[F:31].[n:32]1([O:33][C:34]([N:35]([CH3:36])[CH3:37])=[N+:38]([CH3:39])[CH3:40])[c:41]2[n:42][cH:43][cH:44][cH:45][c:46]2[n:47][n:48]1>>[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:7])[NH:15][CH:12]2[CH2:13][CH2:14]2)[cH:8][c:9]([Cl:11])[n:10]1

Participants

Reactant 6

HCID 6228Dimethylformamide

HCID 9886Hexafluorophosphate

HCID 69828Cyclopropylamine

HCID 81531Diisopropylethylamine

HCID 948302,6-Dichloroisonicotinic acid

HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium

Product 1

HCID 215100262,6-Dichloro-N-cyclopropylisonicotinamide

Sources & evidence

ORD record: ord-b89dcd351ca440ad91cc20d11c494424
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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