Hydrochloric Acid → 2,2,2-Trifluoro-N-[2-(methylsulfonyl)ethyl]-N-[(3-{[4-(2-{3-[(2-thienylacetyl)amino]phenyl}pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinyl]amino}phenyl)methyl]acetamide

HRID 1549561Notes

Reaction equation

HRID 1549561 reaction equation
[CH3:65][CH2:66][O:67][C:68]([CH3:69])=[O:70].[ClH:64].[NH2:1][c:2]1[cH:3][c:4]([CH2:8][N:9]([C:10]([C:11]([F:12])([F:13])[F:14])=[O:15])[CH2:16][CH2:17][S:18](=[O:19])(=[O:20])[CH3:21])[cH:5][cH:6][cH:7]1.[o:22]1[c:23](-[c:24]2[cH:25][c:26]([NH:27][c:34]3[n:35][cH:36][cH:37][c:38](-[c:40]4[c:41](-[c:49]5[cH:50][c:51]([NH:55][C:56]([CH2:57][c:58]6[s:59][cH:60][cH:61][cH:62]6)=[O:63])[cH:52][cH:53][cH:54]5)[n:42][n:43]5[c:44]4[cH:45][cH:46][cH:47][cH:48]5)[n:39]3)[cH:28][cH:29][cH:30]2)[cH:31][n:32][cH:33]1>>[NH:1]([c:2]1[cH:3][c:4]([CH2:8][N:9]([C:10]([C:11]([F:12])([F:13])[F:14])=[O:15])[CH2:16][CH2:17][S:18](=[O:19])(=[O:20])[CH3:21])[cH:5][cH:6][cH:7]1)[c:34]1[n:35][cH:36][cH:37][c:38](-[c:40]2[c:41](-[c:49]3[cH:50][c:51]([NH:55][C:56]([CH2:57][c:58]4[s:59][cH:60][cH:61][cH:62]4)=[O:63])[cH:52][cH:53][cH:54]3)[n:42][n:43]3[c:44]2[cH:45][cH:46][cH:47][cH:48]3)[n:39]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 57737194N-{3-[3-(2-{[3-(1,3-Oxazol-5-yl)phenyl]amino}-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamideHCID 59511431HCID 59511431, compound

Product 1

HCID 577372392,2,2-Trifluoro-N-[2-(methylsulfonyl)ethyl]-N-[(3-{[4-(2-{3-[(2-thienylacetyl)amino]phenyl}pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinyl]amino}phenyl)methyl]acetamide

Sources & evidence

ORD record
ord-aaa444d4328c49dea71fa068d2c1e940
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…