Tetrahydrofuran → tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

HRID 1553083Notes

Reaction equation

HRID 1553083 reaction equation
[Al+3:2].[C:7](#[N:8])[C:9]1([OH:22])[CH2:10][CH2:11][N:12]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:13][CH2:14]1.[CH2:23]1[O:24][CH2:25][CH2:26][CH2:27]1.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3]>>[CH2:7]([NH2:8])[C:9]1([OH:22])[CH2:10][CH2:11][N:12]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:13][CH2:14]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 53399262tert-Butyl 4-cyano-4-hydroxypiperidine-1-carboxylate

Product 1

HCID 23396319tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-e6c5bd1493234109b8baf90b06af1c03
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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