Acetonitrile → 7-Chloro-6-phenyl-2-phenylsulfamoyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid amide

HRID 1553761Notes

Reaction equation

HRID 1553761 reaction equation
[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[CH3:45][C:46]#[N:47].[Cl:8][c:9]1[c:10]([C:24](=[O:25])[NH2:26])[c:11]2[n:12]([c:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH2:13][CH2:14][NH:15][CH2:16]2.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[c:34]1([NH:40][S:41](=[O:42])(=[O:43])[Cl:44])[cH:35][cH:36][cH:37][cH:38][cH:39]1>>[Cl:8][c:9]1[c:10]([C:24](=[O:25])[NH2:26])[c:11]2[n:12]([c:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[CH2:13][CH2:14][N:15]([S:41]([NH:40][c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)(=[O:42])=[O:43])[CH2:16]2

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 11564615Phenylsulfamoyl chlorideHCID 68886671HCID 68886671, compound

Product 1

HCID 587620107-Chloro-6-phenyl-2-phenylsulfamoyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-8-carboxylic acid amide

Sources & evidence

ORD record
ord-2220325aff724868ad699c2647e2c257
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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