Tetrahydrofuran → tert-Butyl 1,3-thiazol-4-yl[(2,4,5-trifluorophenyl)sulfonyl]carbamate

HRID 1554513Notes

Reaction equation

HRID 1554513 reaction equation
[CH3:14][Si:15]([CH3:16])([CH3:17])[N-:18][Si:19]([CH3:20])([CH3:21])[CH3:22].[F:24][c:25]1[c:26]([S:33](=[O:34])(=[O:35])[Cl:36])[cH:27][c:28]([F:32])[c:29]([F:31])[cH:30]1.[Li+:23].[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1.[s:1]1[cH:2][n:3][c:4]([NH:6][C:7]([O:8][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:13])[cH:5]1>>[s:1]1[cH:2][n:3][c:4]([N:6]([C:7]([O:8][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:13])[S:33]([c:26]2[c:25]([F:24])[cH:30][c:29]([F:31])[c:28]([F:32])[cH:27]2)(=[O:34])=[O:35])[cH:5]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 27769792,4,5-Trifluorobenzenesulfonyl chlorideHCID 3280088Npc316347HCID 53241636tert-butyl N-(1,3-thiazol-4-yl)carbamate

Product 1

HCID 59436528tert-Butyl 1,3-thiazol-4-yl[(2,4,5-trifluorophenyl)sulfonyl]carbamate

Sources & evidence

ORD record
ord-ab8fd5b8a5f5480cacd1577d9f97f71b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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