Dimethylformamide → tert-butyl N-[4-[3-[6-chloro-1-(3-methoxypropyl)benzimidazol-2-yl]piperidin-1-yl]-1-naphthalen-2-yl-4-oxobutan-2-yl]carbamate

HRID 1554965Notes

Reaction equation

HRID 1554965 reaction equation
[C:22]([CH3:23])([CH3:24])([CH3:25])[O:26][C:27](=[O:28])[NH:29][CH:30]([CH2:31][C:32](=[O:33])[OH:34])[CH2:35][c:36]1[cH:37][c:38]2[cH:39][cH:40][cH:41][cH:42][c:43]2[cH:44][cH:45]1.[CH3:46][N:47]1[CH2:48][CH2:49][O:50][CH2:51][CH2:52]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]([CH2:16][CH2:17][CH2:18][O:19][CH3:20])[c:8]([CH:10]3[CH2:11][NH:12][CH2:13][CH2:14][CH2:15]3)[n:9]2)[cH:21]1.[O:77]=[CH:78][N:79]([CH3:80])[CH3:81].[P-:53]([F:54])([F:55])([F:56])([F:57])([F:58])[F:59].[n:60]1([O:61][C:62]([N:63]([CH3:64])[CH3:65])=[N+:66]([CH3:67])[CH3:68])[c:69]2[n:70][cH:71][cH:72][cH:73][c:74]2[n:75][n:76]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]([CH2:16][CH2:17][CH2:18][O:19][CH3:20])[c:8]([CH:10]3[CH2:11][N:12]([C:32]([CH2:31][CH:30]([NH:29][C:27]([O:26][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:28])[CH2:35][c:36]4[cH:37][c:38]5[cH:39][cH:40][cH:41][cH:42][c:43]5[cH:44][cH:45]4)=[O:33])[CH2:13][CH2:14][CH2:15]3)[n:9]2)[cH:21]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 79724-MethylmorpholineHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 533979213-(Boc-amino)-4-(2-naphthyl)butyric AcidHCID 667856446-Chloro-1-(3-methoxypropyl)-2-piperidin-3-ylbenzimidazole

Product 1

HCID 77190873tert-butyl N-[4-[3-[6-chloro-1-(3-methoxypropyl)benzimidazol-2-yl]piperidin-1-yl]-1-naphthalen-2-yl-4-oxobutan-2-yl]carbamate

Sources & evidence

ORD record
ord-b11b137c731d4d42bb369c22fb16cc90
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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