Tetrahydrofuran → 2-{(SR)-1-[(3RS,4SR)-1-Benzyl-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethoxy}-5-trifluoromethyl-pyridine
Reaction equation
[CH2:31]([c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)[N:38]1[CH2:39][CH:40]([CH:51]([CH3:52])[OH:53])[CH:41]([c:43]2[cH:44][c:45]([Cl:50])[c:46]([Cl:49])[cH:47][cH:48]2)[CH2:42]1.[CH2:54]1[O:55][CH2:56][CH2:57][CH2:58]1.[F:20][C:21]([c:22]1[cH:23][cH:24][c:25]([OH:28])[n:26][cH:27]1)([F:29])[F:30].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[F:20][C:21]([c:22]1[cH:23][cH:24][c:25]([O:28][CH:51]([CH:40]2[CH2:39][N:38]([CH2:31][c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)[CH2:42][CH:41]2[c:43]2[cH:44][c:45]([Cl:50])[c:46]([Cl:49])[cH:47][cH:48]2)[CH3:52])[n:26][cH:27]1)([F:29])[F:30]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-02da0d0b810548619da59ab1177d0f07
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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